The treated subjects experienced significantly improved skin complexion and skin feeling, profilometrically assessed skin roughness, and ultrasonographically measured collagen density.

Subjects reported clinically significant reduction in pain following 6 out of 8 treatment sessions when treated twice weekly for 4 weeks at 79 seconds per session of near infrared light.

One placebo‐controlled randomized controlled trial of 112 patients found that LED‐RL (633‐nm, 126 J/cm 55 mW/cm2, 20 minutes), LED‐nIR (830‐nm, 55 mW/cm2, 66 J/cm2 , 20 minutes), or combination LED‐RL (50% duty cycle) and LED‐nIR (50% duty cycle) twice weekly for 4 weeks improved wrinkles by 26%, 33%, and 36%, respectively.

In a randomized controlled trial, 30 patients were satisfied when receiving LED Redlight (633‐nm, 50% duty cycle, 1.17 minutes) and LED‐nIR * (880‐nm, 50% duty cycle, 1.17 minutes), radiofrequency, or combination (LED with radiofrequency) treatments after 5–27 treatments over 40–50 days.

Statistically significant reductions in measured nipple lesion area (p<0.001) were observed for both the experimental and control groups with an increase in the number of treatment sessions. A significant difference between the experimental and control groups was observed for the healing of nipple lesions (p<0.001). The pain intensity was significantly reduced only in the experimental group (p<0.001).

Three RCTs used LED‐nIR for the treatment of recurrent facial HSV or HZV. In two placebo‐controlled, double‐blind RCTs of 87 and 32 patients, six treatments of LED‐nIR* (1072‐nm) over 2 days resulted in a 2–3 days reduction in re‐epithelialization time in patients with labial HSV infections by 12–16 days follow‐up. In a RCT of 28 patients with HZV, LED‐nIR (830‐nm, 55 mW/cm2, 33 J/cm2,10 minutes) for four treatments over 10 days with oral famciclovir resulted in reduced healing time, less atrophic scarring, and fewer incidences of post‐inflammatory hyperpigmentation compared to famciclovir alone treatment.